InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Eif2c2

Summary

InnateDB Gene

IDBG-148172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2c2

Gene Name

eukaryotic translation initiation factor 2C, 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036698

Encoded Proteins

IDBP-148174

eukaryotic translation initiation factor 2C, 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123908:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:73095844-73184840

Strand

Reverse strand

Band

Transcripts

ENSMUST00000044113

ENSMUSP00000042207

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000340	RNA 7-methylguanosine cap binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0004521	endoribonuclease activity
GO:0005515	protein binding
GO:0035197	siRNA binding
GO:0035198	miRNA binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0070551	endoribonuclease activity, cleaving siRNA-paired mRNA

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006379	mRNA cleavage
GO:0009791	post-embryonic development
GO:0030154	cell differentiation
GO:0031047	gene silencing by RNA
GO:0031054	pre-miRNA processing
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0035279	mRNA cleavage involved in gene silencing by miRNA
GO:0045947	negative regulation of translational initiation
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005844	polysome
GO:0005845	mRNA cap binding complex
GO:0016020	membrane
GO:0016442	RISC complex
GO:0030529	ribonucleoprotein complex
GO:0035068	micro-ribonucleoprotein complex