Mus musculus Gene: Mapk8
Summary
InnateDB Gene IDBG-148417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapk8
Gene Name mitogen-activated protein kinase 8
Synonyms AI849689; JNK; JNK1; Prkm8; SAPK1;
Species Mus musculus
Ensembl Gene ENSMUSG00000021936
Encoded Proteins
mitogen-activated protein kinase 8
mitogen-activated protein kinase 8
mitogen-activated protein kinase 8
mitogen-activated protein kinase 8
mitogen-activated protein kinase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Phosphorylation of the inflammasome adaptor Pycard (ASC) controls inflammasome activity through the formation of ASC specks. The NLRP3 and AIM2 inflammasomes require Syk and Mapk8 (JNK) for their full activity .
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] MAPK8 phosphorylates IRF3 and is essential for IRF3 dimerization induced by polyinosinic-cytidylic acid (polyI:C).
[Homo sapiens] Mycobacterium tuberculosis phosphatase PtpA suppresses innate immunity by binding to ubiquitin; which, in turn, activates it to dephosphorylate phosphorylated MAPK8 and MAPK14.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107643:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:33377898-33447158
Strand Reverse strand
Band B
Transcripts
ENSMUST00000022504 ENSMUSP00000022504
ENSMUST00000111945 ENSMUSP00000107576
ENSMUST00000111944 ENSMUSP00000107575
ENSMUST00000111943 ENSMUSP00000107574
ENSMUST00000111942 ENSMUSP00000107573
ENSMUST00000150659
ENSMUST00000127143
ENSMUST00000130539
ENSMUST00000132379
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 139 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 139 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004705 JUN kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035033 histone deacetylase regulator activity
GO:0042826 histone deacetylase binding
Biological Process
GO:0001503 ossification
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009411 response to UV
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0031063 regulation of histone deacetylation
GO:0032091 negative regulation of protein binding
GO:0032880 regulation of protein localization
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0046686 response to cadmium ion
GO:0048263 determination of dorsal identity
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071732 cellular response to nitric oxide
GO:0090045 positive regulation of deacetylase activity
GO:0097300 programmed necrotic cell death
GO:2000017 positive regulation of determination of dorsal identity
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Apoptosis pathway
Oxidative Stress Induced Senescence pathway
Activation of the AP-1 family of transcription factors pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Cellular responses to stress pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88 cascade initiated on plasma membrane pathway
NRAGE signals death through JNK pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
DSCAM interactions pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
Activation of BH3-only proteins pathway
Activated TLR4 signalling pathway
Activation of BMF and translocation to mitochondria pathway
MyD88-independent cascade pathway
Activation of BIM and translocation to mitochondria pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
NRIF signals cell death from the nucleus pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
FCERI mediated MAPK activation pathway
Cell-Cell communication pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Wnt signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Pancreatic cancer pathway
INOH
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
TGF-beta signaling pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL6 pathway
RANKL pathway
Leptin pathway
TSLP pathway
TWEAK pathway
Prolactin pathway
REACTOME
Cellular responses to stress pathway
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Cell-Cell communication pathway
MyD88 cascade initiated on plasma membrane pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activation of the AP-1 family of transcription factors pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
Activation of BMF and translocation to mitochondria pathway
p75 NTR receptor-mediated signalling pathway
Activation of BIM and translocation to mitochondria pathway
Apoptosis pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
NRAGE signals death through JNK pathway
Activation of BH3-only proteins pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
NRIF signals cell death from the nucleus pathway
Cellular Senescence pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
DSCAM interactions pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Intrinsic Pathway for Apoptosis pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
FCERI mediated MAPK activation pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Wnt signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Shigellosis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Pancreatic cancer pathway
INOH
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
TGF-beta signaling pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Atm signaling pathway [Biocarta view]
Inhibition of cellular proliferation by gleevec [Biocarta view]
Toll-like receptor pathway [Biocarta view]
Bcr signaling pathway [Biocarta view]
Integrin signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Bone remodeling [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Il12 and stat4 dependent signaling pathway in th1 development [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Signal transduction through il1r [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Fas signaling pathway (cd95) [Biocarta view]
Regulation of map kinase pathways through dual specificity phosphatases [Biocarta view]
Hypoxia and p53 in the cardiovascular system [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Syndecan-2-mediated signaling events
Ceramide signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Reelin signaling pathway
IL1-mediated signaling events
Downstream signaling in na´ve CD8+ T cells
S1P2 pathway
TRAIL signaling pathway
ATF-2 transcription factor network
EPO signaling pathway
Glucocorticoid receptor regulatory network
RAC1 signaling pathway
Endothelins
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Retinoic acid receptors-mediated signaling
Ephrin B reverse signaling
ErbB2/ErbB3 signaling events
JNK signaling in the CD4+ TCR pathway
CDC42 signaling events
Signaling events regulated by Ret tyrosine kinase
Role of Calcineurin-dependent NFAT signaling in lymphocytes
RhoA signaling pathway
Regulation of Androgen receptor activity
Fc-epsilon receptor I signaling in mast cells
N-cadherin signaling events
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.21495 Mm.404866 Mm.406811 Mm.409682 Mm.412411
RefSeq NM_016700 XM_006519030 XM_006519031 XM_006519033
OMIM
CCDS CCDS36869
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas