Version 5.4
Mus musculus Gene: Hif1a
Summary
InnateDB Gene IDBG-148620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hif1a
Gene Name hypoxia inducible factor 1, alpha subunit
Synonyms AA959795; bHLHe78; HIF1alpha; MOP1
Species Mus musculus
Ensembl Gene ENSMUSG00000021109
Encoded Proteins
IDBP-148622
hypoxia inducible factor 1, alpha subunit
IDBP-260221
hypoxia inducible factor 1, alpha subunit
IDBP-260223
hypoxia inducible factor 1, alpha subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21685248
Hif1a, under normoxic conditions, accumulates in dendritic cells via the TLR/Myd88/NFkB signalling pathway to induce a distinct subset of proinflammatory genes in comparison to hypoxia-induced Hif1a.
InnateDB Annotation from Orthologs
Summary
PMID 18606657
[Homo sapiens] HIF1A transcription is induced by IFNA2 in human endothelial cells though a JAK-ISGF3 pathway under normoxic conditions, and that this response contributes to the anti-proliferative activity of this cytokine.
PMID 17965024
[Homo sapiens] HIF1A expression is regulated by intracellular calcium levels, resulting in modulation of PPP3CA (calcineurin) activity and RACK1 dimerization.
PMID 20517715
[Homo sapiens] Hypoxia-inducible factors (HIFs), including HIF1A, regulate glycolytic energy generation, optimize innate immunity, control pro-inflammatory gene expression, mediate bacterial killing and influence cell migration. HIFs contribute to inflammatory functions in various components of innate immunity, such as neutrophils, dendritic cells, mast cells, and epithelial cells.
PMID 20511350
[Homo sapiens] HIF1A, the most ubiquitously expressed hypoxia-inducible factor (HIF), in epithelial cells alters the lung's innate immune response and biases the tissue toward a Th2-mediated inflammation.
PMID 21685248
[Homo sapiens] HIF1A, under normoxic conditions, accumulates in dendritic cells via the TLR/MYD88/NFkB signalling pathway to induce a distinct subset of proinflammatory genes in comparison to hypoxia-induced HIF1A. (Demonstrated in murine model)
PMID 25746953
[Homo sapiens] HIF1A mediates the functional plasticity of monocytes during sepsis, wherein they transit from a pro-inflammatory to an immunosuppressive phenotype, while enhancing protective functions like phagocytosis, anti-microbial activity, and tissue remodelling .
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100644:
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:73901375-73947530
Strand Forward strand
Band C3
Transcripts
ENSMUST00000021530 ENSMUSP00000021530
ENSMUST00000110464 ENSMUSP00000106091
ENSMUST00000110461 ENSMUSP00000106088
ENSMUST00000149740
ENSMUST00000157041
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 33 [view]
Protein-DNA 13 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 135 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035035 histone acetyltransferase binding
GO:0035257 nuclear hormone receptor binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0051879 Hsp90 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001666 response to hypoxia
GO:0001755 neural crest cell migration
GO:0001837 epithelial to mesenchymal transition
GO:0001892 embryonic placenta development
GO:0001922 B-1 B cell homeostasis
GO:0001944 vasculature development
GO:0001947 heart looping
GO:0002052 positive regulation of neuroblast proliferation
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0003151 outflow tract morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0006089 lactate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006879 cellular iron ion homeostasis
GO:0007165 signal transduction
GO:0007595 lactation
GO:0008542 visual learning
GO:0010468 regulation of gene expression
GO:0010573 vascular endothelial growth factor production
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010634 positive regulation of epithelial cell migration
GO:0010870 positive regulation of receptor biosynthetic process
GO:0014850 response to muscle activity
GO:0019896 axon transport of mitochondrion
GO:0021502 neural fold elevation formation
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030502 negative regulation of bone mineralization
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007 negative regulation of TOR signaling
GO:0032364 oxygen homeostasis
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032963 collagen metabolic process
GO:0035162 embryonic hemopoiesis
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127 regulation of cell proliferation
GO:0042541 hemoglobin biosynthetic process
GO:0042593 glucose homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045087 innate immune response (InnateDB)
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045926 negative regulation of growth
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046716 muscle cell cellular homeostasis
GO:0046886 positive regulation of hormone biosynthetic process
GO:0048514 blood vessel morphogenesis
GO:0048546 digestive tract morphogenesis
GO:0050790 regulation of catalytic activity
GO:0051216 cartilage development
GO:0051541 elastin metabolic process
GO:0060574 intestinal epithelial cell maturation
GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development
GO:0061298 retina vasculature development in camera-type eye
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070243 regulation of thymocyte apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0071347 cellular response to interleukin-1
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:2001054 negative regulation of mesenchymal cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031514 motile cilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100644
View Gene Order
ENSBTAG00000020935
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_241925
Circadian Clock pathway
REACT_188957
Cellular responses to stress pathway
REACT_199106
Cellular response to hypoxia pathway
REACT_199108
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_199109
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_199104
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_199107
Regulation of gene expression by Hypoxia-inducible Factor pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_196464
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
KEGG
mmu05211
Renal cell carcinoma pathway
mmu04150
mTOR signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_24941
Circadian Clock pathway
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_121092
Regulation of gene expression by Hypoxia-inducible Factor pathway
REACT_121226
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_120956
Cellular responses to stress pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
ap1_pathway
AP-1 transcription factor network
hif1_tfpathway
HIF-1-alpha transcription factor network
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
vegfr1_pathway
VEGFR1 specific signals
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3879 Mm.397466
RefSeq NM_010431 XM_006515477 XM_006515478
OMIM
CCDS CCDS25977
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca