InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grik2

Summary

InnateDB Gene

IDBG-149430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grik2

Gene Name

glutamate receptor, ionotropic, kainate 2 (beta 2)

Synonyms

AW124492; GluK2; Glur-6; Glur6; Glurbeta2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056073

Encoded Proteins

IDBP-149434

glutamate receptor, ionotropic, kainate 2 (beta 2)

IDBP-270779

glutamate receptor, ionotropic, kainate 2 (beta 2)

IDBP-270781

glutamate receptor, ionotropic, kainate 2 (beta 2)

IDBP-270783

glutamate receptor, ionotropic, kainate 2 (beta 2)

IDBP-270785

glutamate receptor, ionotropic, kainate 2 (beta 2)

IDBP-270787

glutamate receptor, ionotropic, kainate 2 (beta 2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:49099460-49788766

Strand

Reverse strand

Band

Transcripts

ENSMUST00000079751	ENSMUSP00000078687
ENSMUST00000105487	ENSMUSP00000101127
ENSMUST00000105486	ENSMUSP00000101126
ENSMUST00000105485	ENSMUSP00000101125
ENSMUST00000105484	ENSMUSP00000101124
ENSMUST00000105483	ENSMUSP00000101123
ENSMUST00000147808
ENSMUST00000129279

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0015277	kainate selective glutamate receptor activity
GO:0030165	PDZ domain binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001662	behavioral fear response
GO:0006810	transport
GO:0006874	cellular calcium ion homeostasis
GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0019228	neuronal action potential
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0043113	receptor clustering
GO:0043524	negative regulation of neuron apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0046328	regulation of JNK cascade
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0050804	regulation of synaptic transmission
GO:0050806	positive regulation of synaptic transmission
GO:0051402	neuron apoptotic process
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0008328	ionotropic glutamate receptor complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0032839	dendrite cytoplasm
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043204	perikaryon
GO:0045202	synapse
GO:0045211	postsynaptic membrane