Version 5.4
Mus musculus Gene: Hagh
Summary
InnateDB Gene IDBG-149449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hagh
Gene Name hydroxyacyl glutathione hydrolase
Synonyms BC019817; Glo-2; Glo2; Rsp29
Species Mus musculus
Ensembl Gene ENSMUSG00000024158
Encoded Proteins
IDBP-149451
hydroxyacyl glutathione hydrolase
IDBP-401528
hydroxyacyl glutathione hydrolase
IDBP-542365
hydroxyacyl glutathione hydrolase
IDBP-539590
hydroxyacyl glutathione hydrolase
IDBP-534675
hydroxyacyl glutathione hydrolase
IDBP-622940
hydroxyacyl glutathione hydrolase
IDBP-622944
hydroxyacyl glutathione hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000063854:
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:24840143-24864450
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000024974 ENSMUSP00000024974
ENSMUST00000118788 ENSMUSP00000113051
ENSMUST00000154363 ENSMUSP00000114672
ENSMUST00000130989 ENSMUSP00000120734
ENSMUST00000149716 ENSMUSP00000114838
ENSMUST00000164251 ENSMUSP00000129904
ENSMUST00000169200 ENSMUSP00000126514
ENSMUST00000163132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004416 hydroxyacylglutathione hydrolase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
Biological Process
GO:0006750 glutathione biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000063854
View Gene Order
ENSBTAG00000019998
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00620
Pyruvate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00620
Pyruvate metabolism pathway
INOH
INOH website
Pyruvate metabolism pathway
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.43784
RefSeq NM_001159626 NM_024284 XM_006523660 XM_006523661
OMIM
CCDS CCDS28499 CCDS50021
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca