Version 5.4
Mus musculus Gene: Bai1
Summary
InnateDB Gene IDBG-149585.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bai1
Gene Name brain-specific angiogenesis inhibitor 1
Synonyms B830018M07Rik; mKIAA4089; R75078
Species Mus musculus
Ensembl Gene ENSMUSG00000034730
Encoded Proteins
IDBP-149587
brain-specific angiogenesis inhibitor 1
IDBP-623729
brain-specific angiogenesis inhibitor 1
IDBP-789628
brain-specific angiogenesis inhibitor 1
IDBP-789630
brain-specific angiogenesis inhibitor 1
IDBP-789631
brain-specific angiogenesis inhibitor 1
IDBP-789632
brain-specific angiogenesis inhibitor 1
IDBP-789633
brain-specific angiogenesis inhibitor 1
IDBP-789634
brain-specific angiogenesis inhibitor 1
IDBP-789635
brain-specific angiogenesis inhibitor 1
IDBP-789636
brain-specific angiogenesis inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181790:
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one \'functional\' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:74516195-74589465
Strand Forward strand
Band D3
Transcripts
ENSMUST00000042035 ENSMUSP00000046097
ENSMUST00000170845 ENSMUSP00000127122
ENSMUST00000186360 ENSMUSP00000140362
ENSMUST00000187485 ENSMUSP00000140959
ENSMUST00000189200 ENSMUSP00000140713
ENSMUST00000189353 ENSMUSP00000140889
ENSMUST00000190524 ENSMUSP00000140407
ENSMUST00000185682 ENSMUSP00000139428
ENSMUST00000187599 ENSMUSP00000140831
ENSMUST00000186095
ENSMUST00000187639 ENSMUSP00000139954
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0016525 negative regulation of angiogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181790
View Gene Order
ENSBTAG00000006385
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04115
p53 signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_174991 XM_006520273 XM_006520275 XM_006520276
OMIM
CCDS CCDS70635
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca