InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nck2

Summary

InnateDB Gene

IDBG-149650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nck2

Gene Name

non-catalytic region of tyrosine kinase adaptor protein 2

Synonyms

4833426I10Rik; Grb4; Nck-2; NCKbeta

Species

Mus musculus

Ensembl Gene

ENSMUSG00000066877

Encoded Proteins

IDBP-149652

non-catalytic region of tyrosine kinase adaptor protein 2

IDBP-251123

non-catalytic region of tyrosine kinase adaptor protein 2

IDBP-789458

non-catalytic region of tyrosine kinase adaptor protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071051:
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:43444579-43570515

Strand

Forward strand

Band

C1.1

Transcripts

ENSMUST00000086421	ENSMUSP00000083611
ENSMUST00000114744	ENSMUSP00000110392
ENSMUST00000136648
ENSMUST00000124817
ENSMUST00000187435	ENSMUSP00000140338

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006417	regulation of translation
GO:0007015	actin filament organization
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0030838	positive regulation of actin filament polymerization
GO:0042102	positive regulation of T cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter