Version 5.4
Mus musculus Gene: Gnaq
Summary
InnateDB Gene IDBG-149873.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnaq
Gene Name guanine nucleotide binding protein, alpha q polypeptide
Synonyms 1110005L02Rik; 6230401I02Rik; AA408290; AW060788; Dsk1; Dsk10; Galphaq; Gq; GqI
Species Mus musculus
Ensembl Gene ENSMUSG00000024639
Encoded Proteins
IDBP-149875
guanine nucleotide binding protein, alpha q polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156052:
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:16132831-16387463
Strand Forward strand
Band A
Transcripts
ENSMUST00000025541 ENSMUSP00000025541
ENSMUST00000170229
ENSMUST00000167656
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0001501 skeletal system development
GO:0001508 action potential
GO:0006184 GTP catabolic process
GO:0006469 negative regulation of protein kinase activity
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007507 heart development
GO:0009791 post-embryonic development
GO:0016322 neuron remodeling
GO:0021884 forebrain neuron development
GO:0035412 regulation of catenin import into nucleus
GO:0042711 maternal behavior
GO:0042733 embryonic digit morphogenesis
GO:0043547 positive regulation of GTPase activity
GO:0045634 regulation of melanocyte differentiation
GO:0048066 developmental pigmentation
GO:0050821 protein stabilization
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
Cellular Component
GO:0005765 lysosomal membrane
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000156052
View Gene Order
ENSBTAG00000009789
Not yet available
Pathways
NETPATH
REACTOME
REACT_258788
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_223625
GPCR downstream signaling pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_233922
Thromboxane signalling through TP receptor pathway
REACT_254215
Signaling by GPCR pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_247495
Acetylcholine regulates insulin secretion pathway
REACT_188937
Metabolism pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_250548
Platelet sensitization by LDL pathway
REACT_220322
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_259068
ADP signalling through P2Y purinoceptor 1 pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
REACT_251998
Free fatty acids regulate insulin secretion pathway
REACT_251507
Signal amplification pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04916
Melanogenesis pathway
mmu04540
Gap junction pathway
mmu04912
GnRH signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu04730
Long-term depression pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu05016
Huntington's disease pathway
mmu05146
Amoebiasis pathway
mmu04971
Gastric acid secretion pathway
mmu04970
Salivary secretion pathway
mmu04972
Pancreatic secretion pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
mmu05143
African trypanosomiasis pathway
INOH
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
REACTOME
REACT_19140
ADP signalling through P2Y purinoceptor 1 pathway
REACT_20647
Thromboxane signalling through TP receptor pathway
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18405
Acetylcholine regulates insulin secretion pathway
REACT_19193
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_19375
Free fatty acids regulate insulin secretion pathway
REACT_111217
Metabolism pathway
REACT_20524
Signal amplification pathway
REACT_604
Hemostasis pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04730
Long-term depression pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa05016
Huntington's disease pathway
hsa04971
Gastric acid secretion pathway
hsa05146
Amoebiasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa05143
African trypanosomiasis pathway
INOH
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.393198 Mm.411565 Mm.439701
RefSeq NM_008139
OMIM
CCDS CCDS29684
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca