Version 5.4
Mus musculus Gene: Mtm1
Summary
InnateDB Gene IDBG-150322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mtm1
Gene Name X-linked myotubular myopathy gene 1
Synonyms AF073996; mKIAA4176; Mtm
Species Mus musculus
Ensembl Gene ENSMUSG00000031337
Encoded Proteins
IDBP-150324
X-linked myotubular myopathy gene 1
IDBP-150326
X-linked myotubular myopathy gene 1
IDBP-150328
X-linked myotubular myopathy gene 1
IDBP-150332
X-linked myotubular myopathy gene 1
IDBP-251398
X-linked myotubular myopathy gene 1
IDBP-251400
X-linked myotubular myopathy gene 1
IDBP-625421
X-linked myotubular myopathy gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171100:
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:71210767-71315691
Strand Forward strand
Band A7.3
Transcripts
ENSMUST00000061970 ENSMUSP00000057182
ENSMUST00000025391 ENSMUSP00000025391
ENSMUST00000033700 ENSMUSP00000033700
ENSMUST00000101501 ENSMUSP00000099040
ENSMUST00000114621 ENSMUSP00000110268
ENSMUST00000114617 ENSMUSP00000110264
ENSMUST00000134859
ENSMUST00000126208
ENSMUST00000156452
ENSMUST00000151415
ENSMUST00000152810
ENSMUST00000129722
ENSMUST00000171933 ENSMUSP00000125798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0019215 intermediate filament binding
GO:0035091 phosphatidylinositol binding
GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0044088 regulation of vacuole organization
GO:0045109 intermediate filament organization
GO:0046716 muscle cell cellular homeostasis
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048311 mitochondrion distribution
GO:0070584 mitochondrion morphogenesis
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0030175 filopodium
GO:0031674 I band
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171100
View Gene Order
ENSBTAG00000014138
Not yet available
Pathways
NETPATH
REACTOME
REACT_198975
Synthesis of PIPs at the early endosome membrane pathway
REACT_198972
Synthesis of PIPs at the late endosome membrane pathway
REACT_198973
Synthesis of PIPs at the plasma membrane pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_120918
Synthesis of PIPs at the late endosome membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_227888
Synthesis of PIPs at the plasma membrane pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_214431
Synthesis of PIPs at the early endosome membrane pathway
REACT_221945
Synthesis of PIPs at the late endosome membrane pathway
REACT_219139
Metabolism pathway
REACT_218329
Phospholipid metabolism pathway
REACT_227900
PI Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.274981 Mm.415810 Mm.457108
RefSeq NM_001164190 NM_001164191 NM_001164192 NM_001164193 NM_019926 XM_006527891
OMIM
CCDS CCDS30177 CCDS53089 CCDS53090
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca