Version 5.4
Mus musculus Gene: Ercc2
Summary
InnateDB Gene IDBG-150400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ercc2
Gene Name excision repair cross-complementing rodent repair deficiency, complementation group 2
Synonyms AA407812; AU020867; AW240756; CXPD; Ercc-2; XPD
Species Mus musculus
Ensembl Gene ENSMUSG00000030400
Encoded Proteins
IDBP-150402
excision repair cross-complementing rodent repair deficiency, complementation group 2
IDBP-264481
excision repair cross-complementing rodent repair deficiency, complementation group 2
IDBP-264483
excision repair cross-complementing rodent repair deficiency, complementation group 2
IDBP-535474
excision repair cross-complementing rodent repair deficiency, complementation group 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104884:
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:19382010-19395694
Strand Forward strand
Band A3
Transcripts
ENSMUST00000062831 ENSMUSP00000054380
ENSMUST00000108461 ENSMUSP00000104101
ENSMUST00000108460 ENSMUSP00000104100
ENSMUST00000136055
ENSMUST00000127363
ENSMUST00000129249 ENSMUSP00000117840
ENSMUST00000128167
ENSMUST00000129291
ENSMUST00000135693
ENSMUST00000145039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008026 ATP-dependent helicase activity
GO:0008094 DNA-dependent ATPase activity
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0043139 5'-3' DNA helicase activity
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0006139 nucleobase-containing compound metabolic process
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007059 chromosome segregation
GO:0007568 aging
GO:0008283 cell proliferation
GO:0009411 response to UV
GO:0009650 UV protection
GO:0009791 post-embryonic development
GO:0021510 spinal cord development
GO:0022405 hair cycle process
GO:0030198 extracellular matrix organization
GO:0030282 bone mineralization
GO:0032289 central nervous system myelin formation
GO:0032508 DNA duplex unwinding
GO:0033683 nucleotide-excision repair, DNA incision
GO:0035264 multicellular organism growth
GO:0035315 hair cell differentiation
GO:0040016 embryonic cleavage
GO:0043249 erythrocyte maturation
GO:0043388 positive regulation of DNA binding
GO:0043588 skin development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048820 hair follicle maturation
GO:0060218 hematopoietic stem cell differentiation
GO:1901990 regulation of mitotic cell cycle phase transition
Cellular Component
GO:0000439 core TFIIH complex
GO:0005634 nucleus
GO:0005675 holo TFIIH complex
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0071817 MMXD complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104884
View Gene Order
ENSBTAG00000002072
Not yet available
Pathways
NETPATH
REACTOME
REACT_230204
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_203462
Formation of the Early Elongation Complex pathway
REACT_223654
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_240507
Dual incision reaction in GG-NER pathway
REACT_244380
RNA Polymerase II Transcription Initiation pathway
REACT_255334
RNA Polymerase II Promoter Escape pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_252106
Formation of incision complex in GG-NER pathway
REACT_257165
RNA Polymerase I Transcription Termination pathway
REACT_188937
Metabolism pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_226759
Formation of RNA Pol II elongation complex pathway
REACT_232708
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_233397
DNA Repair pathway
REACT_226490
RNA Polymerase II Transcription Elongation pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_196637
Cytosolic iron-sulfur cluster assembly pathway
REACT_258231
mRNA Capping pathway
REACT_233572
Gene Expression pathway
REACT_232235
RNA Polymerase I Promoter Escape pathway
REACT_224562
Dual incision reaction in TC-NER pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_259097
RNA Polymerase I Chain Elongation pathway
REACT_242255
RNA Polymerase II Transcription pathway
REACT_257596
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
KEGG
mmu03022
Basal transcription factors pathway
mmu03420
Nucleotide excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_160176
Cytosolic iron-sulfur cluster assembly pathway
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1470
mRNA Capping pathway
REACT_1655
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_2089
RNA Polymerase II Promoter Escape pathway
REACT_1851
RNA Polymerase II Transcription Initiation pathway
REACT_834
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_975
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6332
HIV Transcription Initiation pathway
REACT_6253
RNA Polymerase II HIV Promoter Escape pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6237
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_1941
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_2222
Dual incision reaction in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_311
Dual incision reaction in GG-NER pathway
REACT_257
Formation of incision complex in GG-NER pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_111217
Metabolism pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_216
DNA Repair pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
KEGG
hsa03022
Basal transcription factors pathway
hsa03420
Nucleotide excision repair pathway
INOH
PID NCI
Cross-References
SwissProt O08811
TrEMBL
UniProt Splice Variant
Entrez Gene 13871
UniGene
RefSeq NM_007949
OMIM
CCDS CCDS20900
HPRD
IMGT
MGI ID MGI:95413
MGI Symbol Ercc2
EMBL AK004652 AK082761 CH466639 U97572
GenPept AAB58296 BAB23443 BAC38607 EDL23140
RNA Seq Atlas 13871

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca