Version 5.4
Homo sapiens Gene: SRGAP3
Summary
InnateDB Gene IDBG-15048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRGAP3
Gene Name SLIT-ROBO Rho GTPase activating protein 3
Synonyms ARHGAP14; MEGAP; SRGAP2; WRP
Species Homo sapiens
Ensembl Gene ENSG00000196220
Encoded Proteins
IDBP-15050
SLIT-ROBO Rho GTPase activating protein 3
IDBP-15052
SLIT-ROBO Rho GTPase activating protein 3
IDBP-810059
SLIT-ROBO Rho GTPase activating protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:8980591-9363053
Strand Reverse strand
Band p25.3
Transcripts
ENST00000383836 ENSP00000373347
ENST00000360413 ENSP00000353587
ENST00000433332
ENST00000491467
ENST00000520860
ENST00000518265
ENST00000475560
ENST00000485983
ENST00000480750
ENST00000470951
ENST00000490348
ENST00000490889
ENST00000618999 ENSP00000482666
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030257
View Gene Order
ENSBTAG00000004685
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_19342
Inactivation of Cdc42 and Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001033117 NM_014850 XM_006713433
HUGO
OMIM
CCDS CCDS2572 CCDS33689
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca