InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ddc

Summary

InnateDB Gene

IDBG-150518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddc

Gene Name

dopa decarboxylase

Synonyms

Aadc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020182

Encoded Proteins

IDBP-150520

dopa decarboxylase

IDBP-261916

dopa decarboxylase

IDBP-541341

dopa decarboxylase

IDBP-718385

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132437:
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:11814101-11898144

Strand

Reverse strand

Band

Transcripts

ENSMUST00000066237	ENSMUSP00000068525
ENSMUST00000109659	ENSMUSP00000105286
ENSMUST00000136810
ENSMUST00000134401
ENSMUST00000122971
ENSMUST00000155690	ENSMUSP00000121096
ENSMUST00000146359
ENSMUST00000145033
ENSMUST00000134121
ENSMUST00000178704	ENSMUSP00000136467

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004058	aromatic-L-amino-acid decarboxylase activity
GO:0005515	protein binding
GO:0016597	amino acid binding
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0019904	protein domain specific binding
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0007623	circadian rhythm
GO:0009636	response to toxic substance
GO:0010259	multicellular organismal aging
GO:0015842	synaptic vesicle amine transport
GO:0019752	carboxylic acid metabolic process
GO:0033076	isoquinoline alkaloid metabolic process
GO:0035690	cellular response to drug
GO:0042416	dopamine biosynthetic process
GO:0042427	serotonin biosynthetic process
GO:0046684	response to pyrethroid
GO:0052314	phytoalexin metabolic process
GO:0071312	cellular response to alkaloid
GO:0071363	cellular response to growth factor stimulus