Version 5.4
Mus musculus Gene: Siae
Summary
InnateDB Gene IDBG-150542.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Siae
Gene Name sialic acid acetylesterase
Synonyms LSE; Ysg2
Species Mus musculus
Ensembl Gene ENSMUSG00000001942
Encoded Proteins
IDBP-150546
sialic acid acetylesterase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110013:
This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:37613847-37648318
Strand Forward strand
Band A4
Transcripts
ENSMUST00000002007 ENSMUSP00000002007
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001681 sialate O-acetylesterase activity
Biological Process
GO:0002682 regulation of immune system process
GO:0005975 carbohydrate metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110013
View Gene Order
ENSBTAG00000009412
Not yet available
Cross-References
SwissProt P70665
TrEMBL C3VDJ0
UniProt Splice Variant
Entrez Gene 22619
UniGene Mm.470448
RefSeq NM_011734 XM_006510154
OMIM
CCDS CCDS22983
HPRD
IMGT
MGI ID MGI:104803
MGI Symbol Siae
EMBL AF156856 AK028598 AK028656 AK033980 AK035715 AK043392 AK164852 AK167103 BC007136 FJ859045 U40408 U61183 X98625
GenPept AAB07813 AAC52880 AAD55976 AAH07136 ACP03817 BAC26026 BAC26049 BAC28536 BAC29164 BAC31534 BAE37942 BAE39252 CAA67214
RNA Seq Atlas 22619

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca