Version 5.4
| Mus musculus Gene: Nrg3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-151248.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Nrg3 | ||||||||||||||||||
| Gene Name | neuregulin 3 | ||||||||||||||||||
| Synonyms | ska | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000041014 | ||||||||||||||||||
| Encoded Proteins |
neuregulin 3
neuregulin 3
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185737:
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 14:38368952-39473088 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | B | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
ErbB signaling pathway pathway
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| INOH |
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
SHC1 events in ERBB4 signaling pathway
Nuclear signaling by ERBB4 pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
GRB2 events in ERBB2 signaling pathway
SHC1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
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| KEGG |
ErbB signaling pathway pathway
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| INOH |
GPCR signaling pathway
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| PID NCI |
ErbB4 signaling events
ErbB receptor signaling network
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Mm.258705 | ||||||||||||||||||
| RefSeq | NM_001190187 NM_001190188 NM_008734 XM_006518685 XM_006518686 XM_006518687 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS26954 CCDS49450 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | |||||||||||||||||||
| MGI Symbol | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||