Mus musculus Gene: Gpx2 | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-151265.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Gpx2 | ||||||||||||
Gene Name | glutathione peroxidase 2 | ||||||||||||
Synonyms | GI-GPx; GPx-GI; GSHPx-2; GSHPx-GI | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Gene | ENSMUSG00000042808 | ||||||||||||
Encoded Proteins |
glutathione peroxidase 2
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Knockout studies in mice indicate that mRNA expression and activity of this enzyme are induced by luminal microflora, suggesting a role for this peroxidase in preventing inflammation in the GI tract. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 12:76792335-76795554 | ||||||||||||
Strand | Reverse strand | ||||||||||||
Band | C3 | ||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Cellular responses to stress pathway
Detoxification of Reactive Oxygen Species pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Synthesis of 15-eicosatetraenoic acid derivatives pathway
Arachidonic acid metabolism pathway
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KEGG |
Glutathione metabolism pathway
Arachidonic acid metabolism pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Synthesis of 15-eicosatetraenoic acid derivatives pathway
Synthesis of 5-eicosatetraenoic acids pathway
Synthesis of 12-eicosatetraenoic acid derivatives pathway
Arachidonic acid metabolism pathway
Cellular responses to stress pathway
Metabolism of lipids and lipoproteins pathway
Detoxification of Reactive Oxygen Species pathway
Metabolism pathway
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KEGG |
Arachidonic acid metabolism pathway
Glutathione metabolism pathway
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INOH | |||||||||||||
PID NCI |
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
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Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | |||||||||||||
UniGene | Mm.441856 Mm.57225 | ||||||||||||
RefSeq | NM_030677 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS25996 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
MGI ID | |||||||||||||
MGI Symbol | |||||||||||||
EMBL | |||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | |||||||||||||