Mus musculus Gene: Max | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-151490.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Max | ||||||||||||||||||||||
Gene Name | Max protein | ||||||||||||||||||||||
Synonyms | AA960152; AI875693; bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000059436 | ||||||||||||||||||||||
Encoded Proteins |
Max protein
Max protein
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125952:
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:76937269-76962248 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | C3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
MAPK signaling pathway pathway
Small cell lung cancer pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cyclin A:Cdk2-associated events at S phase entry pathway
Cyclin E associated events during G1/S transition pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
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KEGG |
MAPK signaling pathway pathway
Small cell lung cancer pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Validated targets of C-MYC transcriptional repression
Validated targets of C-MYC transcriptional activation
Signaling events mediated by HDAC Class I
C-MYC pathway
Regulation of nuclear SMAD2/3 signaling
Regulation of Telomerase
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | B2RS19 Q8C4Y1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 17187 | ||||||||||||||||||||||
UniGene | Mm.268548 Mm.489923 | ||||||||||||||||||||||
RefSeq | NM_001146176 NM_008558 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS36479 CCDS49094 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:96921 | ||||||||||||||||||||||
MGI Symbol | Max | ||||||||||||||||||||||
EMBL | AC124556 AK080431 BC138671 BC138672 BC145369 | ||||||||||||||||||||||
GenPept | AAI38672 AAI38673 AAI45370 BAC37914 | ||||||||||||||||||||||
RNA Seq Atlas | 17187 | ||||||||||||||||||||||