Version 5.4
Mus musculus Gene: Plek
Summary
InnateDB Gene IDBG-151611.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plek
Gene Name pleckstrin
Synonyms 2010300B13Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000020120
Encoded Proteins
IDBP-151613
pleckstrin
IDBP-151615
pleckstrin
IDBP-533401
pleckstrin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115956:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:16971206-17052381
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000102881 ENSMUSP00000099945
ENSMUST00000020321 ENSMUSP00000020321
ENSMUST00000156101 ENSMUSP00000122225
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002576 platelet degranulation
GO:0006904 vesicle docking involved in exocytosis
GO:0007229 integrin-mediated signaling pathway
GO:0010572 positive regulation of platelet activation
GO:0010920 negative regulation of inositol phosphate biosynthetic process
GO:0010925 positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0030030 cell projection organization
GO:0030836 positive regulation of actin filament depolymerization
GO:0030845 phospholipase C-inhibiting G-protein coupled receptor signaling pathway
GO:0030866 cortical actin cytoskeleton organization
GO:0031529 ruffle organization
GO:0031532 actin cytoskeleton reorganization
GO:0032233 positive regulation of actin filament bundle assembly
GO:0033625 positive regulation of integrin activation
GO:0035556 intracellular signal transduction
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0046488 phosphatidylinositol metabolic process
GO:0060305 regulation of cell diameter
GO:0070493 thrombin receptor signaling pathway
GO:0070527 platelet aggregation
GO:0070528 protein kinase C signaling
GO:0070560 protein secretion by platelet
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115956
View Gene Order
ENSBTAG00000009658
Not yet available
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5F270
UniProt Splice Variant
Entrez Gene 56193
UniGene Mm.98232
RefSeq NM_019549
OMIM
CCDS CCDS24446
HPRD
IMGT
MGI ID MGI:1860485
MGI Symbol Plek
EMBL AL606466
GenPept
RNA Seq Atlas 56193

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca