Version 5.4
Mus musculus Gene: Tsta3
Summary
InnateDB Gene IDBG-151936.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tsta3
Gene Name tissue specific transplantation antigen P35B
Synonyms AI256181; FX; Tstap35b
Species Mus musculus
Ensembl Gene ENSMUSG00000022570
Encoded Proteins
IDBP-151938
tissue specific transplantation antigen P35B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104522:
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:75924684-75929730
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000023231 ENSMUSP00000023231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008831 dTDP-4-dehydrorhamnose reductase activity
GO:0016853 isomerase activity
GO:0050577 GDP-L-fucose synthase activity
GO:0050662 coenzyme binding
Biological Process
GO:0019673 GDP-mannose metabolic process
GO:0019835 cytolysis
GO:0042351 'de novo' GDP-L-fucose biosynthetic process
GO:0044237 cellular metabolic process
GO:0045226 extracellular polysaccharide biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104522
View Gene Order
ENSBTAG00000034691
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
mmu00051
Fructose and mannose metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt P23591
TrEMBL Q5HZI6
UniProt Splice Variant
Entrez Gene 22122
UniGene Mm.22596
RefSeq NM_031201 XM_006520751
OMIM
CCDS CCDS27555
HPRD
IMGT
MGI ID MGI:98857
MGI Symbol Tsta3
EMBL AK029632 BC089003 CH466545 M30127 M30128 X53620 X53621 X53622 X53623 X53624 X53625 X53626 X53627 X53628
GenPept AAA39673 AAA39674 AAH89003 BAC26539 CAB94217 EDL29503
RNA Seq Atlas 22122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca