Mus musculus Gene: Eif2s1
Summary
InnateDB Gene IDBG-152187.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2s1
Gene Name eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms 0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a; eIF2alpha;
Species Mus musculus
Ensembl Gene ENSMUSG00000021116
Encoded Proteins
eukaryotic translation initiation factor 2, subunit 1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134001:
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:78861819-78887010
Strand Forward strand
Band C3
Transcripts
ENSMUST00000071230 ENSMUSP00000071214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0043558 regulation of translational initiation in response to stress
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Unfolded Protein Response (UPR) pathway
Translation pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
PERK regulates gene expression pathway
Eukaryotic Translation Initiation pathway
Gene Expression pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Recycling of eIF2:GDP pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
KEGG
RNA transport pathway
Protein processing in endoplasmic reticulum pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
IL1 pathway
REACTOME
Eukaryotic Translation Initiation pathway
Unfolded Protein Response (UPR) pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
Recycling of eIF2:GDP pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
PERK regulates gene expression pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Eukaryotic Translation Initiation pathway
Cap-dependent Translation Initiation pathway
Translation pathway
Recycling of eIF2:GDP pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Metabolism of proteins pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation initiation complex formation pathway
Unfolded Protein Response (UPR) pathway
Ribosomal scanning and start codon recognition pathway
KEGG
RNA transport pathway
Protein processing in endoplasmic reticulum pathway
Hepatitis C pathway
INOH
PID BIOCARTA
Double stranded rna induced gene expression [Biocarta view]
Regulation of eif2 [Biocarta view]
Eukaryotic protein translation [Biocarta view]
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
PID NCI
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.196220 Mm.405568 Mm.412353
RefSeq NM_026114
OMIM
CCDS CCDS26003
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas