InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: S1pr3

Summary

InnateDB Gene

IDBG-152199.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1pr3

Gene Name

sphingosine-1-phosphate receptor 3

Synonyms

AI132464; Edg3; Lpb3; S1p3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000067586

Encoded Proteins

IDBP-152201

sphingosine-1-phosphate receptor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:51408618-51422797

Strand

Forward strand

Band

Transcripts

ENSMUST00000087978

ENSMUSP00000085293

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005178	integrin binding
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0001816	cytokine production
GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0032651	regulation of interleukin-1 beta production
GO:1903141	negative regulation of establishment of endothelial barrier