InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sstr5

Summary

InnateDB Gene

IDBG-152272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sstr5

Gene Name

somatostatin receptor 5

Synonyms

Smstr5; sst5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000050824

Encoded Proteins

IDBP-152274

somatostatin receptor 5

IDBP-623812

somatostatin receptor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162009:
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:25489875-25497288

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000051864	ENSMUSP00000051085
ENSMUST00000165183	ENSMUSP00000128787

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0032467	positive regulation of cytokinesis
GO:0038170	somatostatin signaling pathway
GO:0042593	glucose homeostasis
GO:0050796	regulation of insulin secretion