InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scrib

Summary

InnateDB Gene

IDBG-152337.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scrib

Gene Name

scribbled homolog (Drosophila)

Synonyms

AI118201; Crc; CRIB; mKIAA0147; Scrb1; SCRIB1; vartul

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022568

Encoded Proteins

IDBP-152339

scribbled homolog (Drosophila)

IDBP-152341

scribbled homolog (Drosophila)

IDBP-261285

scribbled homolog (Drosophila)

IDBP-539493

scribbled homolog (Drosophila)

IDBP-540578

scribbled homolog (Drosophila)

IDBP-537918

scribbled homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180900:
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:76047158-76069784

Strand

Reverse strand

Band

Transcripts

ENSMUST00000063747	ENSMUSP00000068056
ENSMUST00000002603	ENSMUSP00000002603
ENSMUST00000109946	ENSMUSP00000105572
ENSMUST00000136390	ENSMUSP00000119097
ENSMUST00000145830	ENSMUSP00000115329
ENSMUST00000148211	ENSMUSP00000114573

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001843	neural tube closure
GO:0001921	positive regulation of receptor recycling
GO:0002093	auditory receptor cell morphogenesis
GO:0008105	asymmetric protein localization
GO:0008283	cell proliferation
GO:0016080	synaptic vesicle targeting
GO:0016331	morphogenesis of embryonic epithelium
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration
GO:0021747	cochlear nucleus development
GO:0032863	activation of Rac GTPase activity
GO:0035089	establishment of apical/basal cell polarity
GO:0042060	wound healing
GO:0043065	positive regulation of apoptotic process
GO:0043615	astrocyte cell migration
GO:0045930	negative regulation of mitotic cell cycle
GO:0048488	synaptic vesicle endocytosis
GO:0050918	positive chemotaxis
GO:0060088	auditory receptor cell stereocilium organization
GO:0060561	apoptotic process involved in morphogenesis
GO:0060603	mammary gland duct morphogenesis
GO:0071896	protein localization to adherens junction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0016323	basolateral plasma membrane
GO:0030027	lamellipodium
GO:0031252	cell leading edge
GO:0034750	Scrib-APC-beta-catenin complex
GO:0035748	myelin sheath abaxonal region
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome