Version 5.4
Mus musculus Gene: Gadd45g
Summary
InnateDB Gene IDBG-152599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gadd45g
Gene Name growth arrest and DNA-damage-inducible 45 gamma
Synonyms AI327420; C86281; CR6; DDIT2; OIG37
Species Mus musculus
Ensembl Gene ENSMUSG00000021453
Encoded Proteins
IDBP-152601
growth arrest and DNA-damage-inducible 45 gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130222:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:51846678-51848468
Strand Forward strand
Band A5
Transcripts
ENSMUST00000021903 ENSMUSP00000021903
ENSMUST00000132480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000185 activation of MAPKKK activity
GO:0000186 activation of MAPKK activity
GO:0006469 negative regulation of protein kinase activity
GO:0006950 response to stress
GO:0042095 interferon-gamma biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0045063 T-helper 1 cell differentiation
GO:0046330 positive regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:1900745 positive regulation of p38MAPK cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130222
View Gene Order
ENSBTAG00000003033
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04115
p53 signaling pathway pathway
mmu04110
Cell cycle pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04110
Cell cycle pathway
hsa04010
MAPK signaling pathway pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
il12_2pathway
IL12-mediated signaling events
Cross-References
SwissProt
TrEMBL Q9R0S0
UniProt Splice Variant
Entrez Gene 23882
UniGene
RefSeq NM_011817
OMIM
CCDS CCDS26515
HPRD
IMGT
MGI ID MGI:1346325
MGI Symbol Gadd45g
EMBL AB021884 AC126247 AY258502 CH466546
GenPept AAP79506 BAA78538 EDL41110
RNA Seq Atlas 23882

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca