InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apod

Summary

InnateDB Gene

IDBG-152863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apod

Gene Name

apolipoprotein D

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022548

Encoded Proteins

IDBP-250095

apolipoprotein D

IDBP-536495

apolipoprotein D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a component of high-density lipoprotein (HDL), but is unique in that it shares greater structural similarity to lipocalin than to other members of the apolipoprotein family, and has a wider tissue expression pattern. The encoded protein is involved in lipid metabolism, and ablation of this gene results in defects in triglyceride metabolism. Elevated levels of this gene product have been observed in multiple tissues of Niemann-Pick disease mouse models, as well as in some tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:31296192-31314808

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023207
ENSMUST00000115230	ENSMUSP00000110885
ENSMUST00000130560	ENSMUSP00000119827
ENSMUST00000156456
ENSMUST00000155682
ENSMUST00000145837

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0015485	cholesterol binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0006006	glucose metabolic process
GO:0006629	lipid metabolic process
GO:0006810	transport
GO:0007420	brain development
GO:0007568	aging
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014012	peripheral nervous system axon regeneration
GO:0042246	tissue regeneration
GO:0042308	negative regulation of protein import into nucleus
GO:0042493	response to drug
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048678	response to axon injury
GO:0051895	negative regulation of focal adhesion assembly
GO:0060588	negative regulation of lipoprotein lipid oxidation
GO:0071638	negative regulation of monocyte chemotactic protein-1 production
GO:1900016	negative regulation of cytokine production involved in inflammatory response
GO:2000098	negative regulation of smooth muscle cell-matrix adhesion
GO:2000405	negative regulation of T cell migration

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005783	endoplasmic reticulum
GO:0022626	cytosolic ribosome
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000189058

View Gene Order

ENSBTAG00000023600

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_23892

Transport of fatty acids pathway

REACT_22285

Transport of vitamins, nucleosides, and related molecules pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_267716

Orphan transporters pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2082 Mm.416437 Mm.474879

RefSeq

NM_007470 XM_006521716 XM_006521717

OMIM

CCDS

CCDS28105

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas