Version 5.4
Mus musculus Gene: Ppid
Summary
InnateDB Gene IDBG-153114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppid
Gene Name peptidylprolyl isomerase D (cyclophilin D)
Synonyms 4930564J03Rik; CYP-40; Ppidl; Ppif
Species Mus musculus
Ensembl Gene ENSMUSG00000027804
Encoded Proteins
IDBP-153116
peptidylprolyl isomerase D (cyclophilin D)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171497:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:79591342-79603650
Strand Forward strand
Band E3
Transcripts
ENSMUST00000029382 ENSMUSP00000029382
ENSMUST00000161460
ENSMUST00000162690
ENSMUST00000159505
ENSMUST00000161876
ENSMUST00000160799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0008134 transcription factor binding
GO:0030331 estrogen receptor binding
GO:0030544 Hsp70 protein binding
GO:0031072 heat shock protein binding
GO:0042277 peptide binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0015031 protein transport
GO:0034389 lipid particle organization
GO:0043065 positive regulation of apoptotic process
GO:0045070 positive regulation of viral genome replication
GO:0050714 positive regulation of protein secretion
GO:0061077 chaperone-mediated protein folding
GO:0071492 cellular response to UV-A
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171497
View Gene Order
ENSBTAG00000016680
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.295252 Mm.407122
RefSeq NM_026352
OMIM
CCDS CCDS17417
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca