Homo sapiens Gene: RAD1
Summary
InnateDB Gene IDBG-15336.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD1
Gene Name RAD1 homolog (S. pombe)
Synonyms HRAD1; REC1;
Species Homo sapiens
Ensembl Gene ENSG00000113456
Encoded Proteins
RAD1 homolog (S. pombe)
RAD1 homolog (S. pombe)
RAD1 homolog (S. pombe)
RAD1 homolog (S. pombe)
RAD1 homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:34905264-34918989
Strand Reverse strand
Band p13.2
Transcripts
ENST00000382038 ENSP00000371469
ENST00000341754 ENSP00000340879
ENST00000325577 ENSP00000313467
ENST00000513914 ENSP00000421007
ENST00000511456 ENSP00000423253
ENST00000512192
ENST00000506311
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0008853 exodeoxyribonuclease III activity
Biological Process
GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007128 meiotic prophase I
GO:0021762 substantia nigra development
GO:0071479 cellular response to ionizing radiation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G2/M Checkpoints pathway
Cell Cycle pathway
Activation of ATR in response to replication stress pathway
Cell Cycle Checkpoints pathway
KEGG
INOH
PID BIOCARTA
Role of brca1 brca2 and atr in cancer susceptibility [Biocarta view]
PID NCI
Fanconi anemia pathway
ATR signaling pathway
Regulation of Telomerase
Cross-References
SwissProt O60671
TrEMBL A0A024R045
UniProt Splice Variant
Entrez Gene 5810
UniGene Hs.38114 Hs.625647 Hs.669185 Hs.713947
RefSeq NM_002853
HUGO HGNC:9806
OMIM 603153
CCDS CCDS3905
HPRD 04400
IMGT
EMBL AB183821 AB183822 AF011905 AF030933 AF058392 AF073524 AF074717 AF076841 AF084512 AF084513 AF090170 AJ004974 AJ004975 AK002112 BC006837 BC009804 BC037857 BT006908 CH471119 DQ451401
GenPept AAC14138 AAC27243 AAC35549 AAC35550 AAC95427 AAC95466 AAC95523 AAC95603 AAC98093 AAH06837 AAH09804 AAH37857 AAP35554 ABD96829 BAD86789 BAD86790 BAG51017 CAA06248 CAA06249 EAW55904 EAW55906 EAW55907 EAW55908
RNA Seq Atlas 5810