InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAD1

Summary

InnateDB Gene

IDBG-15336.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD1

Gene Name

RAD1 homolog (S. pombe)

Synonyms

HRAD1; REC1

Species

Homo sapiens

Ensembl Gene

ENSG00000113456

Encoded Proteins

IDBP-15338

RAD1 homolog (S. pombe)

IDBP-15344

RAD1 homolog (S. pombe)

IDBP-15346

RAD1 homolog (S. pombe)

IDBP-481692

RAD1 homolog (S. pombe)

IDBP-484784

RAD1 homolog (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:34905264-34918989

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000382038	ENSP00000371469
ENST00000341754	ENSP00000340879
ENST00000325577	ENSP00000313467
ENST00000513914	ENSP00000421007
ENST00000511456	ENSP00000423253
ENST00000512192
ENST00000506311

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0008853	exodeoxyribonuclease III activity

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000077	DNA damage checkpoint
GO:0000738	DNA catabolic process, exonucleolytic
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007128	meiotic prophase I
GO:0021762	substantia nigra development
GO:0071479	cellular response to ionizing radiation
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022248

View Gene Order

ENSBTAG00000019209

Not yet available

Pathways

NETPATH

REACTOME

REACT_6769

Activation of ATR in response to replication stress pathway

REACT_828

G2/M Checkpoints pathway

REACT_115566

Cell Cycle pathway

REACT_1538

Cell Cycle Checkpoints pathway

KEGG

INOH

PID NCI

fanconi_pathway

Fanconi anemia pathway

atr_pathway

ATR signaling pathway

telomerasepathway

Regulation of Telomerase

Cross-References

SwissProt

O60671

TrEMBL

A0A024R045 D6R9A1

UniProt Splice Variant

Entrez Gene

5810

UniGene

Hs.38114 Hs.625647 Hs.669185 Hs.713947

RefSeq

NM_002853

HUGO

HGNC:9806

OMIM

603153

CCDS

CCDS3905

HPRD

IMGT

EMBL

AB183821 AB183822 AC026801 AF011905 AF030933 AF058392 AF073524 AF074717 AF076841 AF084512 AF084513 AF090170 AJ004974 AJ004975 AK002112 BC006837 BC009804 BC037857 BT006908 CH471119 DQ451401

GenPept

AAC14138 AAC27243 AAC35549 AAC35550 AAC95427 AAC95466 AAC95523 AAC95603 AAC98093 AAH06837 AAH09804 AAH37857 AAP35554 ABD96829 BAD86789 BAD86790 BAG51017 CAA06248 CAA06249 EAW55904 EAW55906 EAW55907 EAW55908

RNA Seq Atlas

5810