Version 5.4
Mus musculus Gene: Setx
Summary
InnateDB Gene IDBG-153367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Setx
Gene Name senataxin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000043535
Encoded Proteins
IDBP-153369
senataxin
IDBP-532866
senataxin
IDBP-532908
senataxin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107290:
This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:29124181-29182471
Strand Forward strand
Band B
Transcripts
ENSMUST00000061578 ENSMUSP00000051492
ENSMUST00000129544 ENSMUSP00000119521
ENSMUST00000154910
ENSMUST00000135992
ENSMUST00000145422 ENSMUSP00000119176
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006302 double-strand break repair
GO:0006369 termination of RNA polymerase II transcription
GO:0007623 circadian rhythm
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107290
View Gene Order
ENSBTAG00000024822
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 269254
UniGene Mm.404861 Mm.41867 Mm.472481
RefSeq NM_198033 XM_006498084
OMIM
CCDS CCDS38090
HPRD
IMGT
MGI ID MGI:2443480
MGI Symbol Setx
EMBL
GenPept
RNA Seq Atlas 269254

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca