InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gria2

Summary

InnateDB Gene

IDBG-153567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gria2

Gene Name

glutamate receptor, ionotropic, AMPA2 (alpha 2)

Synonyms

GluA2; Glur-2; GluR-B; Glur2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033981

Encoded Proteins

IDBP-153569

glutamate receptor, ionotropic, AMPA2 (alpha 2)

IDBP-266010

glutamate receptor, ionotropic, AMPA2 (alpha 2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:80684936-80802791

Strand

Reverse strand

Band

Transcripts

ENSMUST00000075316	ENSMUSP00000074787
ENSMUST00000107745	ENSMUSP00000103374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0007268	synaptic transmission
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane