Version 5.4
Mus musculus Gene: Pak2
Summary
InnateDB Gene IDBG-153570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pak2
Gene Name p21 protein (Cdc42/Rac)-activated kinase 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022781
Encoded Proteins
IDBP-153572
p21 protein (Cdc42/Rac)-activated kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180370:
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:32016290-32079342
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000023467 ENSMUSP00000023467
ENSMUST00000125019
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 81 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0030296 protein tyrosine kinase activator activity
GO:0042802 identical protein binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007409 axonogenesis
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000180370
View Gene Order
ENSBTAG00000047856
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_258521
Apoptosis pathway
REACT_227951
Signaling by VEGF pathway
REACT_254306
Sema3A PAK dependent Axon repulsion pathway
REACT_230745
Immune System pathway
REACT_221567
Signaling by Robo receptor pathway
REACT_227606
Regulation of Apoptosis pathway
REACT_261451
CD28 dependent Vav1 pathway pathway
REACT_204081
CD28 co-stimulation pathway
REACT_223446
Regulation of PAK-2p34 activity by PS-GAP/RHG10 pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_211941
Stimulation of the cell death response by PAK-2p34 pathway
REACT_218318
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_263034
Semaphorin interactions pathway
REACT_188257
Signal Transduction pathway
REACT_225768
Generation of second messenger molecules pathway
REACT_188530
FCERI mediated MAPK activation pathway
REACT_260744
Activation of Rac pathway
REACT_222648
TCR signaling pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
mmu04360
Axon guidance pathway
mmu05211
Renal cell carcinoma pathway
mmu04012
ErbB signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu04510
Focal adhesion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12623
Generation of second messenger molecules pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_13528
Regulation of PAK-2p34 activity by PS-GAP/RHG10 pathway
REACT_13464
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
REACT_13532
Stimulation of the cell death response by PAK-2p34 pathway
REACT_995
Apoptotic execution phase pathway
REACT_11068
Nef and signal transduction pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19226
Activation of Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_12526
TCR signaling pathway
REACT_19271
Semaphorin interactions pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228226
Ephrin signaling pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_6185
HIV Infection pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_13648
Regulation of Apoptosis pathway
REACT_116125
Disease pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
rac1_pathway
RAC1 signaling pathway
myc_pathway
C-MYC pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt Q8CIN4
TrEMBL Q5DTJ2 Q811J8 Q8BGF1 Q8BVX1 Q8K0Z3
UniProt Splice Variant
Entrez Gene 224105
UniGene Mm.234204 Mm.397635 Mm.475288 Mm.475490
RefSeq NM_177326 XM_006522072
OMIM
CCDS CCDS28112
HPRD
IMGT
MGI ID MGI:1339984
MGI Symbol Pak2
EMBL AK037417 AK038324 AK076227 AK220528 AY167030 BC029195 BC043712 BC086650
GenPept AAH29195 AAH43712 AAH86650 AAN65624 BAC29802 BAC29970 BAC36261 BAD90309
RNA Seq Atlas 224105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca