InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gadd45a

Summary

InnateDB Gene

IDBG-153723.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gadd45a

Gene Name

growth arrest and DNA-damage-inducible 45 alpha

Synonyms

AA545191; Ddit1; GADD45

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036390

Encoded Proteins

IDBP-153725

growth arrest and DNA-damage-inducible 45 alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116717:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:67035096-67037457

Strand

Reverse strand

Band

Transcripts

ENSMUST00000043098	ENSMUSP00000044034
ENSMUST00000151958
ENSMUST00000128617
ENSMUST00000126194
ENSMUST00000155041

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0005515	protein binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0006469	negative regulation of protein kinase activity
GO:0007050	cell cycle arrest
GO:0007098	centrosome cycle
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:0071260	cellular response to mechanical stimulus
GO:0071479	cellular response to ionizing radiation
GO:1900745	positive regulation of p38MAPK cascade
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000116717

View Gene Order

ENSBTAG00000013860

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04115

p53 signaling pathway pathway

mmu04110

Cell cycle pathway

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04110

Cell cycle pathway

hsa04010

MAPK signaling pathway pathway

hsa04115

p53 signaling pathway pathway

INOH

PID NCI

aurora_a_pathway

Aurora A signaling

p53downstreampathway

Direct p53 effectors

atf2_pathway

ATF-2 transcription factor network

myc_represspathway

Validated targets of C-MYC transcriptional repression

foxopathway

FoxO family signaling

tap63pathway

Validated transcriptional targets of TAp63 isoforms

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.72235

RefSeq

NM_007836

OMIM

CCDS

CCDS20217

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas