InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Idh3g

Summary

InnateDB Gene

IDBG-153764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Idh3g

Gene Name

isocitrate dehydrogenase 3 (NAD+), gamma

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002010

Encoded Proteins

IDBP-153766

isocitrate dehydrogenase 3 (NAD+), gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067829:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:73778963-73786897

Strand

Reverse strand

Band

A7.3

Transcripts

ENSMUST00000052761	ENSMUSP00000056502
ENSMUST00000156299
ENSMUST00000129070
ENSMUST00000148419
ENSMUST00000130119
ENSMUST00000140944
ENSMUST00000142707
ENSMUST00000129367
ENSMUST00000145341

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004449	isocitrate dehydrogenase (NAD+) activity
GO:0005524	ATP binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding