Version 5.4
Mus musculus Gene: Il12rb2
Summary
InnateDB Gene IDBG-153874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il12rb2
Gene Name interleukin 12 receptor, beta 2
Synonyms A930027I18Rik; Ifnm; IL-12RB2
Species Mus musculus
Ensembl Gene ENSMUSG00000018341
Encoded Proteins
IDBP-153876
interleukin 12 receptor, beta 2
IDBP-401173
interleukin 12 receptor, beta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081985:
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn\'s disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:67291318-67376188
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000018485 ENSMUSP00000010605
ENSMUST00000117441 ENSMUSP00000113267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 5 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032609 interferon-gamma production
GO:0032729 positive regulation of interferon-gamma production
GO:0034097 response to cytokine
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000081985
View Gene Order
ENSBTAG00000009455
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-12 signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-12 signaling pathway
PID NCI
il27pathway
IL27-mediated signaling events
il12_2pathway
IL12-mediated signaling events
Cross-References
SwissProt P97378
TrEMBL D3Z6H5
UniProt Splice Variant
Entrez Gene 16162
UniGene Mm.188337
RefSeq NM_008354 XM_006505617
OMIM
CCDS CCDS20220
HPRD
IMGT
MGI ID MGI:1270861
MGI Symbol Il12rb2
EMBL AC130822 BC137745 U64199
GenPept AAB36676 AAI37746
RNA Seq Atlas 16162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca