Homo sapiens Gene: TPM1
Summary
InnateDB Gene IDBG-15400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPM1
Gene Name tropomyosin 1 (alpha)
Synonyms C15orf13; CMD1Y; CMH3; HTM-alpha; LVNC9; TMSA;
Species Homo sapiens
Ensembl Gene ENSG00000140416
Encoded Proteins
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
tropomyosin 1 (alpha)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:63042632-63071915
Strand Forward strand
Band q22.2
Transcripts
ENST00000358278 ENSP00000351022
ENST00000317516 ENSP00000322577
ENST00000288398 ENSP00000288398
ENST00000357980 ENSP00000350667
ENST00000267996 ENSP00000267996
ENST00000334895 ENSP00000334624
ENST00000404484 ENSP00000384315
ENST00000403994 ENSP00000385107
ENST00000560975
ENST00000560445 ENSP00000452999
ENST00000561425 ENSP00000453324
ENST00000558314
ENST00000558347 ENSP00000452887
ENST00000559556 ENSP00000453941
ENST00000559397 ENSP00000452879
ENST00000560970 ENSP00000453062
ENST00000561266 ENSP00000453955
ENST00000559831 ENSP00000452977
ENST00000558544 ENSP00000453817
ENST00000558868
ENST00000560959 ENSP00000453724
ENST00000559281 ENSP00000452658
ENST00000560615 ENSP00000453050
ENST00000560679 ENSP00000453136
ENST00000558264 ENSP00000452624
ENST00000558400
ENST00000561395 ENSP00000453092
ENST00000561242
ENST00000558072
ENST00000559108
ENST00000558910 ENSP00000452830
ENST00000560131
ENST00000610733 ENSP00000477929
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0008092 cytoskeletal protein binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0001701 in utero embryonic development
GO:0003065 positive regulation of heart rate by epinephrine
GO:0006928 cellular component movement
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0007010 cytoskeleton organization
GO:0008016 regulation of heart contraction
GO:0030049 muscle filament sliding
GO:0030336 negative regulation of cell migration
GO:0031529 ruffle organization
GO:0032781 positive regulation of ATPase activity
GO:0034614 cellular response to reactive oxygen species
GO:0042060 wound healing
GO:0045214 sarcomere organization
GO:0045785 positive regulation of cell adhesion
GO:0051496 positive regulation of stress fiber assembly
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005862 muscle thin filament tropomyosin
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0031941 filamentous actin
GO:0032059 bleb
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Smooth Muscle Contraction pathway
Muscle contraction pathway
Striated Muscle Contraction pathway
KEGG
Cardiac muscle contraction pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YK20
UniProt Splice Variant
Entrez Gene 7168
UniGene Hs.635569 Hs.713685
RefSeq NM_001018004 NM_001018006 NM_000366 NM_001018005 NM_001018020 NM_001018007 NM_001018008 NM_001301289 XM_006720668 XM_005254637 XM_005254653 XM_005254652 XM_005254646 XM_005254650 XM_005254651 XM_005254648 XM_005254644
HUGO HGNC:12010
OMIM 191010
CCDS CCDS32263 CCDS10181 CCDS45273 CCDS58369 CCDS58368 CCDS32262 CCDS32264
HPRD 01839
IMGT
EMBL AC079328
GenPept
RNA Seq Atlas 7168