InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gucy1a3

Summary

InnateDB Gene

IDBG-154234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gucy1a3

Gene Name

guanylate cyclase 1, soluble, alpha 3

Synonyms

1200016O07Rik; sGC-alpha1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033910

Encoded Proteins

IDBP-154238

guanylate cyclase 1, soluble, alpha 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164116:
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3\',5\'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:82092428-82145877

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048976

ENSMUSP00000048918

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0005525	GTP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0008217	regulation of blood pressure
GO:0009190	cyclic nucleotide biosynthetic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0035556	intracellular signal transduction
GO:0052565	response to defense-related host nitric oxide production
GO:0060087	relaxation of vascular smooth muscle