Version 5.4
Mus musculus Gene: Tnk2
Summary
InnateDB Gene IDBG-154521.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnk2
Gene Name tyrosine kinase, non-receptor, 2
Synonyms Ack; Ack-1; Ack1; Cdgip; Pyk1
Species Mus musculus
Ensembl Gene ENSMUSG00000022791
Encoded Proteins
IDBP-250318
tyrosine kinase, non-receptor, 2
IDBP-250320
tyrosine kinase, non-receptor, 2
IDBP-250322
tyrosine kinase, non-receptor, 2
IDBP-250324
tyrosine kinase, non-receptor, 2
IDBP-250326
tyrosine kinase, non-receptor, 2
IDBP-250328
tyrosine kinase, non-receptor, 2
IDBP-250330
tyrosine kinase, non-receptor, 2
IDBP-621734
tyrosine kinase, non-receptor, 2
IDBP-621735
tyrosine kinase, non-receptor, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000061938:
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:32643874-32683493
Strand Forward strand
Band B3
Transcripts
ENSMUST00000115126 ENSMUSP00000110779
ENSMUST00000115125 ENSMUSP00000110778
ENSMUST00000115124 ENSMUSP00000110777
ENSMUST00000115123 ENSMUSP00000110776
ENSMUST00000115122 ENSMUSP00000110775
ENSMUST00000115121 ENSMUSP00000110774
ENSMUST00000115120 ENSMUSP00000110773
ENSMUST00000145627
ENSMUST00000124585
ENSMUST00000150383
ENSMUST00000156614
ENSMUST00000137044
ENSMUST00000131238 ENSMUSP00000129382
ENSMUST00000152361 ENSMUSP00000125905
ENSMUST00000164358
ENSMUST00000168506
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
GO:0050699 WW domain binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006897 endocytosis
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:2000369 regulation of clathrin-mediated endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0005912 adherens junction
GO:0016020 membrane
GO:0030136 clathrin-coated vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030659 cytoplasmic vesicle membrane
GO:0043025 neuronal cell body
GO:0070436 Grb2-EGFR complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000061938
View Gene Order
ENSBTAG00000021364
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
cdc42_pathway
CDC42 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.251115
RefSeq NM_001110147 NM_001289443 NM_016788 XM_006522332 XM_006522334 XM_006522335 XM_006522336 XM_006522338 XM_006522339 XM_006522341 XM_006522343 XM_006522344 XM_006522345
OMIM
CCDS CCDS37313 CCDS49828
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca