InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fxn

Summary

InnateDB Gene

IDBG-154568.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fxn

Gene Name

frataxin

Synonyms

FA; FARR; Frda; X25

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059363

Encoded Proteins

IDBP-154570

frataxin

IDBP-542114

frataxin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165060:
This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:24261453-24280605

Strand

Reverse strand

Band

Transcripts

ENSMUST00000081333	ENSMUSP00000080081
ENSMUST00000123684	ENSMUSP00000117047
ENSMUST00000132688

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004322	ferroxidase activity
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0008199	ferric iron binding
GO:0034986	iron chaperone activity
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006119	oxidative phosphorylation
GO:0006783	heme biosynthetic process
GO:0006811	ion transport
GO:0006879	cellular iron ion homeostasis
GO:0007005	mitochondrion organization
GO:0007628	adult walking behavior
GO:0008284	positive regulation of cell proliferation
GO:0009060	aerobic respiration
GO:0009792	embryo development ending in birth or egg hatching
GO:0010039	response to iron ion
GO:0010722	regulation of ferrochelatase activity
GO:0016226	iron-sulfur cluster assembly
GO:0016540	protein autoprocessing
GO:0018283	iron incorporation into metallo-sulfur cluster
GO:0019230	proprioception
GO:0030307	positive regulation of cell growth
GO:0040015	negative regulation of multicellular organism growth
GO:0043066	negative regulation of apoptotic process
GO:0046621	negative regulation of organ growth
GO:0048554	positive regulation of metalloenzyme activity
GO:0051347	positive regulation of transferase activity
GO:0051349	positive regulation of lyase activity
GO:0051353	positive regulation of oxidoreductase activity
GO:0055114	oxidation-reduction process
GO:0070301	cellular response to hydrogen peroxide
GO:0090201	negative regulation of release of cytochrome c from mitochondria