InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ing2

Summary

InnateDB Gene

IDBG-154718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ing2

Gene Name

inhibitor of growth family, member 2

Synonyms

2810011M06Rik; Ing1l; Ing2b; P33ING2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000063049

Encoded Proteins

IDBP-154720

inhibitor of growth family, member 2

IDBP-536725

inhibitor of growth family, member 2

IDBP-542148

inhibitor of growth family, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168556:
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. [provided by RefSeq, Jul 2008]
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:47667178-47675556

Strand

Reverse strand

Band

B1.1

Transcripts

ENSMUST00000080353	ENSMUSP00000079226
ENSMUST00000146625	ENSMUSP00000124454
ENSMUST00000125536	ENSMUSP00000124792

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0032403	protein complex binding
GO:0035064	methylated histone binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0008285	negative regulation of cell proliferation
GO:0016568	chromatin modification
GO:0030317	sperm motility
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0040008	regulation of growth
GO:0043065	positive regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048133	male germ-line stem cell division
GO:0072520	seminiferous tubule development
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0016580	Sin3 complex
GO:0016602	CCAAT-binding factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000168556

View Gene Order

ENSBTAG00000047706

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.430733

RefSeq

NM_023503

OMIM

CCDS

CCDS22298

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas