Version 5.4
| Mus musculus Gene: Irak1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-154747.6 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | Irak1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | interleukin-1 receptor-associated kinase 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | AA408924; Il1rak; IRAK; IRAK-1; IRAK1-S; mPLK; Plpk | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000031392 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
interleukin-1 receptor-associated kinase 1
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
Irak1 is polyubiquitinated and disassembled during endotoxin tolerization; a process which impairs the production of LPS-induced pro-inflammatory cytokines without inhibition expression of anti-inflammatory or anti-microbial mediators.
Irak1 mediates the proteasome-dependent degradation of Traf6 and acts as a negative regulator of TLR-signalling.
IRAK1 accumulation triggers ischemia-induced inflammation in the small intestine.
Mir146 attenuates sepsis-induced cardiac dysfunction by preventing NFκB activation, inflammatory cell infiltration, and inflammatory cytokine production via targeting of Irak1 and Traf6 in both cardiomyocytes and inflammatory monocytic cells
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] IRAK1 plays an essential role in Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) -associated NF-kappaB activation through its involvement in IKK activation, which then leads to subsequent IkappaB degradation and NF-kappaB nuclear translocation and both cytosolic and nuclear actions of IRAK1 participate in the activation of NF-kappaB-dependent transcriptional events.
[Homo sapiens] IRAK1 and IRAK4 play key roles in a signalling pathway by which bacterial infection or interleukin-1 (IL1) trigger the production of inflammatory mediators. Pellino isoforms are the E3 ubiquitin ligases that mediate the IL1-stimulated formation of K63-pUb-IRAK1 in cells, which contribute to the activation of IKBKB and NF-kappaB, as well as other signalling pathways dependent on IRAK1 and IRAK4.
[Homo sapiens] IRAK1 is a component of a novel signal transduction pathway through which TNF receptor activates NF-kappaB-dependent gene expression.
[Homo sapiens] IRAK1 plays an essential proximal role in coordinating multiple IL1 signalling pathways for optimal induction of cellular responses.
[Homo sapiens] IRAK1 functionally associates with PKC-epsilon and VASP in the regulation of macrophage migration.
[Homo sapiens] IRAK1 and MYD88 autosomal recessive deficiencies impair Toll-like receptor (TLR)- and interleukin-1 receptor-mediated immunity and predispose patients to recurrent life-threatening bacterial diseases, such as invasive pneumococcal disease in particular, in infancy and early childhood, with weak signs of inflammation.
[Homo sapiens] IRAK1 is polyubiquitinated and disassembled during endotoxin tolerization; a process which impairs the production of LPS-induced pro-inflammatory cytokines without inhibition expression of anti-inflammatory or anti-microbial mediators.
[Homo sapiens] IRAK1 mediates the proteasome-dependent degradation of TRAF6 and acts as a negative regulator of TLR-signalling. (Demonstrated in mice)
[Homo sapiens] IRAK1 accumulation triggers ischemia-induced inflammation in the small intestine.
[Homo sapiens] MIR146A is a potent negative regulator of the innate immune response in keratinocytes through downregulation of the IRAK1/TRAF6/NFκB pathway.
[Homo sapiens] Endotoxin tolerance re-programs TLR4 signalling via suppression of PELI1, a positive regulator of MyD88- and TIR domain-containing adapter inducing IFN-β (TRIF)-dependent signalling that promotes K63-linked polyubiquitination of IRAK1, TBK1, and TAK1.
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184216:
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome X:74013914-74023918 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | A7.3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pathways | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
activated TAK1 mediates p38 MAPK activation pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
p75NTR recruits signalling complexes pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
NOD1/2 Signaling Pathway pathway
p75NTR signals via NF-kB pathway
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
NF-kB is activated and signals survival pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Activated TLR4 signalling pathway
Interleukin-1 signaling pathway
MyD88-independent cascade pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
IRAK1 recruits IKK complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KEGG |
Toll-like receptor signaling pathway pathway
Apoptosis pathway
Neurotrophin signaling pathway pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Chagas disease (American trypanosomiasis) pathway
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| INOH |
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH |
IL1 pathway
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
activated TAK1 mediates p38 MAPK activation pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
IRAK1 recruits IKK complex pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
NOD1/2 Signaling Pathway pathway
Interleukin-1 signaling pathway
p75NTR recruits signalling complexes pathway
NF-kB is activated and signals survival pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
NOD1/2 Signaling Pathway pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
activated TAK1 mediates p38 MAPK activation pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
MAP kinase activation in TLR cascade pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
NF-kB is activated and signals survival pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
p75NTR recruits signalling complexes pathway
Signalling by NGF pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MyD88 dependent cascade initiated on endosome pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
p75 NTR receptor-mediated signalling pathway
Innate Immune System pathway
Interleukin-1 signaling pathway
Signaling by Interleukins pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
IRAK1 recruits IKK complex pathway
MyD88 cascade initiated on plasma membrane pathway
p75NTR signals via NF-kB pathway
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KEGG |
Apoptosis pathway
Toll-like receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| INOH |
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PID NCI |
IL1-mediated signaling events
p75(NTR)-mediated signaling
Endogenous TLR signaling
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Mm.38241 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001177973 NM_001177974 NM_001177975 NM_001177976 NM_008363 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS30219 CCDS53103 CCDS53104 CCDS53105 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||