InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sharpin

Summary

InnateDB Gene

IDBG-154756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sharpin

Gene Name

SHANK-associated RH domain interacting protein

Synonyms

0610041B22Rik; AW121341; cpdm; RBCKL1; SIPL1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022552

Encoded Proteins

IDBP-154758

SHANK-associated RH domain interacting protein

IDBP-541973

SHANK-associated RH domain interacting protein

IDBP-538102

SHANK-associated RH domain interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21709223

Sharpin is an essential adaptor downstream of Ikbkg in the TLR signalling pathway. A mutation in the Sharpin gene impairs Il12 production in TLR-stimulated macrophages.

PMID 22348129

Sharpin deficient dendritic cells show reduced inflammatory cytokine production, defective NF-kB signalling and skewing towards a Th2-response.

InnateDB Annotation from Orthologs

Summary

PMID 21709223

[Homo sapiens] SHARPIN is an essential adaptor downstream of IKBKG in the TLR signalling pathway. A mutation in the SHARPIN gene impairs IL12 production in TLR-stimulated macrophages.

PMID 22348129

[Homo sapiens] SHARPIN deficient dendritic cells show reduced inflammatory cytokine production, defective NF-kB signalling and skewing towards a Th2-response. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179526:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:76347040-76351111

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023211	ENSMUSP00000023211
ENSMUST00000123112
ENSMUST00000144816
ENSMUST00000154477
ENSMUST00000159429	ENSMUSP00000124755
ENSMUST00000147001
ENSMUST00000160560	ENSMUSP00000125382
ENSMUST00000152151
ENSMUST00000137106
ENSMUST00000133993

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031593	polyubiquitin binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding

Biological Process

GO:0007005	mitochondrion organization
GO:0007420	brain development
GO:0008544	epidermis development
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
GO:0030262	apoptotic nuclear changes
GO:0031424	keratinization
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0050728	negative regulation of inflammatory response
GO:0051260	protein homooligomerization
GO:0097039	protein linear polyubiquitination
GO:2000348	regulation of CD40 signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030425	dendrite
GO:0071797	LUBAC complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000179526

View Gene Order

ENSBTAG00000012235

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.403205 Mm.41463

RefSeq

NM_025340

OMIM

CCDS

CCDS37121

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas