Version 5.4
Mus musculus Gene: Pdia2
Summary
InnateDB Gene IDBG-154856.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdia2
Gene Name protein disulfide isomerase associated 2
Synonyms 1810041F13Rik; AI661267; Pdip; Pdipl
Species Mus musculus
Ensembl Gene ENSMUSG00000024184
Encoded Proteins
IDBP-154858
protein disulfide isomerase associated 2
IDBP-401405
protein disulfide isomerase associated 2
IDBP-532366
protein disulfide isomerase associated 2
IDBP-533351
protein disulfide isomerase associated 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185615:
Protein disulfide isomerases (EC 5.3.4.1), such as PDIP, are endoplasmic reticulum (ER) resident proteins that catalyze protein folding and thiol-disulfide interchange reactions (Desilva et al., 1996 [PubMed 8561901]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:26195999-26199087
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000039113 ENSMUSP00000035584
ENSMUST00000120333 ENSMUSP00000114080
ENSMUST00000148134 ENSMUSP00000116340
ENSMUST00000142410 ENSMUSP00000115267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0016853 isomerase activity
GO:0031545 peptidyl-proline 4-dioxygenase activity
Biological Process
GO:0006457 protein folding
GO:0019511 peptidyl-proline hydroxylation
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185615
View Gene Order
ENSBTAG00000016575
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.32631
RefSeq NM_001081070
OMIM
CCDS CCDS37510
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca