Version 5.4
Mus musculus Gene: Dctd
Summary
InnateDB Gene IDBG-154883.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dctd
Gene Name dCMP deaminase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031562
Encoded Proteins
IDBP-154885
dCMP deaminase
IDBP-619697
dCMP deaminase
IDBP-619698
dCMP deaminase
IDBP-619700
dCMP deaminase
IDBP-619701
dCMP deaminase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129187:
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:48099092-48153233
Strand Forward strand
Band B1.1
Transcripts
ENSMUST00000033966 ENSMUSP00000033966
ENSMUST00000098773
ENSMUST00000174278 ENSMUSP00000133445
ENSMUST00000170263 ENSMUSP00000126733
ENSMUST00000174818 ENSMUSP00000134003
ENSMUST00000173991
ENSMUST00000174379 ENSMUSP00000134195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004132 dCMP deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009165 nucleotide biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129187
View Gene Order
ENSBTAG00000020282
Not yet available
Pathways
NETPATH
REACTOME
REACT_238763
Pyrimidine biosynthesis pathway
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_21376
Pyrimidine biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt Q8K2D6
TrEMBL G3UYS1 G3X908 Q3UUA6
UniProt Splice Variant
Entrez Gene 320685
UniGene Mm.121549 Mm.406717
RefSeq NM_001161515 NM_001161516 NM_178788 XM_006509442
OMIM
CCDS CCDS22302
HPRD
IMGT
MGI ID MGI:2444529
MGI Symbol Dctd
EMBL AC164420 AK031645 AK039066 AK077663 AK138614 BC031719 CH466554
GenPept AAH31719 BAC27492 BAC30229 BAC36937 BAE23721 EDL35617 EDL35618
RNA Seq Atlas 320685

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca