InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pcbd1

Summary

InnateDB Gene

IDBG-155077.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcbd1

Gene Name

pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1

Synonyms

Dcoh; Pcbd; Pcd; Phs

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020098

Encoded Proteins

IDBP-155079

pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

SSummary: This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:61089343-61094328

Strand

Forward strand

Band

Transcripts

ENSMUST00000020298

ENSMUSP00000020298

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004505	phenylalanine 4-monooxygenase activity
GO:0005515	protein binding
GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0043496	regulation of protein homodimerization activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051289	protein homotetramerization
GO:0051291	protein heterooligomerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000166228

View Gene Order

ENSBTAG00000011866

Not yet available

Pathways

NETPATH

REACTOME

REACT_261966

Phenylalanine and tyrosine catabolism pathway

REACT_188937

Metabolism pathway

REACT_232845

Metabolism of amino acids and derivatives pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1786

Phenylalanine and tyrosine catabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

REACT_226362

Metabolism of amino acids and derivatives pathway

REACT_227399

Phenylalanine and tyrosine catabolism pathway

REACT_219139

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_025273

OMIM

CCDS

CCDS35913

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas