Version 5.4
Mus musculus Gene: Taz
Summary
InnateDB Gene IDBG-155632.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Taz
Gene Name tafazzin
Synonyms 5031411C02Rik; 9130012G04Rik; AW107266; AW552613; G4.5
Species Mus musculus
Ensembl Gene ENSMUSG00000009995
Encoded Proteins
IDBP-155634
tafazzin
IDBP-715951
IDBP-252299
tafazzin
IDBP-716964
IDBP-533675
tafazzin
IDBP-714867
IDBP-540765
tafazzin
IDBP-538272
tafazzin
IDBP-541229
tafazzin
IDBP-715808
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial phospholipid-lysophospholipid transacylase necessary for normal composition and content of cardiolipin. In humans, mutations of this gene result in Barth syndrome, most often characterized by cardioskeletal myopathy, neutropenia and abnormal mitochondria. This gene is distinct from the gene encoding transcriptional coactivator with PDZ binding motif. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:74281912-74290151
Strand Forward strand
Band A7.3
Transcripts
ENSMUST00000069722 ENSMUSP00000065270
ENSMUST00000114182 ENSMUSP00000135593
ENSMUST00000114180 ENSMUSP00000109818
ENSMUST00000146260
ENSMUST00000135012
ENSMUST00000147844
ENSMUST00000124200 ENSMUSP00000134745
ENSMUST00000156212
ENSMUST00000156880
ENSMUST00000149055
ENSMUST00000156072
ENSMUST00000135504 ENSMUSP00000114496
ENSMUST00000132437 ENSMUSP00000135308
ENSMUST00000134914
ENSMUST00000125972
ENSMUST00000134936
ENSMUST00000153459
ENSMUST00000124915 ENSMUSP00000121031
ENSMUST00000131116 ENSMUSP00000117206
ENSMUST00000134432 ENSMUSP00000115153
ENSMUST00000156788
ENSMUST00000176453 ENSMUSP00000135013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016746 transferase activity, transferring acyl groups
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity
Biological Process
GO:0006936 muscle contraction
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0008152 metabolic process
GO:0030097 hemopoiesis
GO:0032049 cardiolipin biosynthetic process
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0042407 cristae formation
GO:0042775 mitochondrial ATP synthesis coupled electron transport
GO:0048738 cardiac muscle tissue development
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102125
View Gene Order
ENSBTAG00000007456
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_121006
Acyl chain remodeling of CL pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_17015
Metabolism of proteins pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.268483 Mm.397851 Mm.415383
RefSeq NM_001173547 NM_001242615 NM_001242616 NM_001290738 NM_181516 XM_006528244 XM_006528245 XM_006528246 XM_006528249 XM_006528250 XM_006528251
OMIM
CCDS CCDS30224 CCDS53107 CCDS57764 CCDS72400
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca