Version 5.4
Mus musculus Gene: Tnfsf15
Summary
InnateDB Gene IDBG-155748.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfsf15
Gene Name tumor necrosis factor (ligand) superfamily, member 15
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000050395
Encoded Proteins
IDBP-155750
tumor necrosis factor (ligand) superfamily, member 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181634:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:63727084-63745113
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000062246 ENSMUSP00000050144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005123 death receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 immune response
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0042107 cytokine metabolic process
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181634
View Gene Order
ENSBTAG00000018069
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B2RR33 F6VXB8
UniProt Splice Variant
Entrez Gene 326623
UniGene Mm.208152
RefSeq NM_177371
OMIM
CCDS CCDS18263
HPRD
IMGT
MGI ID MGI:2180140
MGI Symbol Tnfsf15
EMBL AL691468 BC138207 BC138208 CH466527
GenPept AAI38208 AAI38209 EDL31092
RNA Seq Atlas 326623

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca