Version 5.4
Mus musculus Gene: Sh3d19
Summary
InnateDB Gene IDBG-155808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3d19
Gene Name SH3 domain protein D19
Synonyms AW011754; Kryn
Species Mus musculus
Ensembl Gene ENSMUSG00000028082
Encoded Proteins
IDBP-266187
SH3 domain protein D19
IDBP-789915
SH3 domain protein D19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109686:
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:85971109-86130526
Strand Forward strand
Band F1
Transcripts
ENSMUST00000107664 ENSMUSP00000103291
ENSMUST00000182969
ENSMUST00000182723
ENSMUST00000183119
ENSMUST00000182399
ENSMUST00000182666 ENSMUSP00000138320
ENSMUST00000183202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070064 proline-rich region binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0022604 regulation of cell morphogenesis
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109686
View Gene Order
ENSBTAG00000016813
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q91X43
TrEMBL
UniProt Splice Variant
Entrez Gene 27059
UniGene Mm.2454 Mm.406736
RefSeq NM_001082414 XM_006501546 XM_006501547 XM_006501548 XM_006501550
OMIM
CCDS CCDS38469
HPRD
IMGT
MGI ID MGI:1350923
MGI Symbol Sh3d19
EMBL AC133508 AF003234 AK050185 BC012633 BC031117 D89677
GenPept AAB82091 AAH12633 AAH31117 BAA19686 BAC34114
RNA Seq Atlas 27059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca