InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vrk2

Summary

InnateDB Gene

IDBG-156163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vrk2

Gene Name

vaccinia related kinase 2

Synonyms

2810003O05Rik; AI447698

Species

Mus musculus

Ensembl Gene

ENSMUSG00000064090

Encoded Proteins

IDBP-156165

vaccinia related kinase 2

IDBP-262248

vaccinia related kinase 2

IDBP-536494

vaccinia related kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000028116:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:26471322-26593999

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000078362	ENSMUSP00000077471
ENSMUST00000109504	ENSMUSP00000105130
ENSMUST00000124294
ENSMUST00000133487
ENSMUST00000155728
ENSMUST00000156264	ENSMUSP00000119928
ENSMUST00000125545

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0034599	cellular response to oxidative stress
GO:0043408	regulation of MAPK cascade
GO:0046777	protein autophosphorylation
GO:2000659	regulation of interleukin-1-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000028116

View Gene Order

ENSBTAG00000033801

Not yet available

Cross-References

SwissProt

Q8BN21

TrEMBL

Q5SP86

UniProt Splice Variant

Entrez Gene

69922

UniGene

Mm.285351

RefSeq

NM_001252447 NM_027260 XM_006514801 XM_006514802

OMIM

CCDS

CCDS24486

HPRD

IMGT

MGI ID

MGI:1917172

MGI Symbol

Vrk2

EMBL

AC083815 AF513620 AK012664 AK053297 AK154485 AL929272 BC013520

GenPept

AAH13520 AAN64922 BAB28393 BAC35335 BAE32620 CAI52021

RNA Seq Atlas

69922