Mus musculus Gene: Vrk2
Summary
InnateDB Gene IDBG-156163.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vrk2
Gene Name vaccinia related kinase 2
Synonyms 2810003O05Rik; AI447698;
Species Mus musculus
Ensembl Gene ENSMUSG00000064090
Encoded Proteins
vaccinia related kinase 2
vaccinia related kinase 2
vaccinia related kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000028116:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:26471322-26593999
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000078362 ENSMUSP00000077471
ENSMUST00000109504 ENSMUSP00000105130
ENSMUST00000124294
ENSMUST00000133487
ENSMUST00000155728
ENSMUST00000156264 ENSMUSP00000119928
ENSMUST00000125545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0034599 cellular response to oxidative stress
GO:0043408 regulation of MAPK cascade
GO:0046777 protein autophosphorylation
GO:2000659 regulation of interleukin-1-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL Q5SP86
UniProt Splice Variant
Entrez Gene 69922
UniGene Mm.285351
RefSeq NM_027260 NM_001252447 XM_006514802 XM_006514801
OMIM
CCDS CCDS24486
HPRD
IMGT
MGI ID MGI:1917172
MGI Symbol Vrk2
EMBL AC083815 AL929272
GenPept
RNA Seq Atlas 69922