Version 5.4
Mus musculus Gene: Pou2f2
Summary
InnateDB Gene IDBG-156347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pou2f2
Gene Name POU domain, class 2, transcription factor 2
Synonyms Oct-2; Oct2a; Oct2b; Otf-2; Otf2
Species Mus musculus
Ensembl Gene ENSMUSG00000008496
Encoded Proteins
IDBP-156351
POU domain, class 2, transcription factor 2
IDBP-264579
POU domain, class 2, transcription factor 2
IDBP-264581
POU domain, class 2, transcription factor 2
IDBP-264583
POU domain, class 2, transcription factor 2
IDBP-264585
POU domain, class 2, transcription factor 2
IDBP-264589
POU domain, class 2, transcription factor 2
IDBP-542540
POU domain, class 2, transcription factor 2
IDBP-722246
IDBP-722397
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000028277:
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5\'-ATTTGCAT-3\', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:25087344-25159922
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000098679 ENSMUSP00000096276
ENSMUST00000108418 ENSMUSP00000104056
ENSMUST00000108417 ENSMUSP00000104055
ENSMUST00000108416 ENSMUSP00000104054
ENSMUST00000108415 ENSMUSP00000104053
ENSMUST00000108413 ENSMUSP00000104051
ENSMUST00000147146 ENSMUSP00000118307
ENSMUST00000176408 ENSMUSP00000135326
ENSMUST00000175774 ENSMUSP00000135075
ENSMUST00000175754
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002335 mature B cell differentiation
GO:0002380 immunoglobulin secretion involved in immune response
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048305 immunoglobulin secretion
GO:0048469 cell maturation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000028277
View Gene Order
ENSBTAG00000008556
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
bcr_5pathway
BCR signaling pathway
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.76683
RefSeq NM_001163554 NM_001163555 NM_001163556 NM_011138 XM_006539656 XM_006539659 XM_006539661 XM_006539662
OMIM
CCDS CCDS39834 CCDS52143 CCDS52144 CCDS52145
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca