Version 5.4
Mus musculus Gene: Rgs12
Summary
InnateDB Gene IDBG-156421.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs12
Gene Name regulator of G-protein signaling 12
Synonyms 1200016K18Rik; 4632412M04Rik; AI481290; E130309H11
Species Mus musculus
Ensembl Gene ENSMUSG00000029101
Encoded Proteins
IDBP-156423
regulator of G-protein signaling 12
IDBP-156425
regulator of G-protein signaling 12
IDBP-252064
regulator of G-protein signaling 12
IDBP-252066
regulator of G-protein signaling 12
IDBP-252068
regulator of G-protein signaling 12
IDBP-252070
regulator of G-protein signaling 12
IDBP-252072
regulator of G-protein signaling 12
IDBP-534983
regulator of G-protein signaling 12
IDBP-532850
regulator of G-protein signaling 12
IDBP-540841
regulator of G-protein signaling 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159788:
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of the \'regulator of G protein signaling\' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:34949445-35039644
Strand Forward strand
Band B2
Transcripts
ENSMUST00000030984 ENSMUSP00000030984
ENSMUST00000087684 ENSMUSP00000084970
ENSMUST00000114285 ENSMUSP00000109924
ENSMUST00000114284 ENSMUSP00000109923
ENSMUST00000114283 ENSMUSP00000109922
ENSMUST00000114281 ENSMUSP00000109920
ENSMUST00000114280 ENSMUSP00000109919
ENSMUST00000128161
ENSMUST00000153972
ENSMUST00000156339 ENSMUSP00000115064
ENSMUST00000141562
ENSMUST00000135403
ENSMUST00000156819 ENSMUSP00000116913
ENSMUST00000155162
ENSMUST00000150139 ENSMUSP00000117158
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0030695 GTPase regulator activity
Biological Process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159788
View Gene Order
ENSBTAG00000016714
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.196208 Mm.468465
RefSeq NM_001163512 NM_173402 XM_006504120 XM_006504121 XM_006504122 XM_006504124 XM_006504125 XM_006504126
OMIM
CCDS CCDS19222 CCDS51472
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca