Mus musculus Gene: Mylk | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-156493.6 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | Mylk | ||||||||||||||||
Gene Name | myosin, light polypeptide kinase | ||||||||||||||||
Synonyms | 9530072E15Rik; A930019C19Rik; AW489456; KRP; Mlck; MLCK108; MLCK210; nmMlck; smMLCK | ||||||||||||||||
Species | Mus musculus | ||||||||||||||||
Ensembl Gene | ENSMUSG00000022836 | ||||||||||||||||
Encoded Proteins |
myosin, light polypeptide kinase
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065534:
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008] This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3\' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 16:34745210-35002420 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | B3 | ||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||
NETPATH | |||||||||||||||||
REACTOME | |||||||||||||||||
KEGG |
Calcium signaling pathway pathway
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
Vascular smooth muscle contraction pathway
Gastric acid secretion pathway
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INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
TNFalpha pathway
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REACTOME |
Smooth Muscle Contraction pathway
Muscle contraction pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
Calcium signaling pathway pathway
Vascular smooth muscle contraction pathway
Gastric acid secretion pathway
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INOH | |||||||||||||||||
PID NCI |
Aurora B signaling
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | |||||||||||||||||
UniGene | Mm.33360 Mm.401121 | ||||||||||||||||
RefSeq | NM_139300 XM_006521702 XM_006521703 XM_006521705 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | CCDS37320 | ||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
MGI ID | |||||||||||||||||
MGI Symbol | |||||||||||||||||
EMBL | |||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | |||||||||||||||||