InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tcf4

Summary

InnateDB Gene

IDBG-156674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcf4

Gene Name

transcription factor 4

Synonyms

5730422P05Rik; ASP-I2; bHLHb19; E2-2; E2.2; ITF-2; ITF-2b; ITF2; ME2; MITF-2A; MITF-2B; SEF-2; SEF2; SEF2-1; Tcf-4; TFE

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053477

Encoded Proteins

IDBP-156676

transcription factor 4

IDBP-156678

transcription factor 4

IDBP-250615

transcription factor 4

IDBP-250617

transcription factor 4

IDBP-250619

transcription factor 4

IDBP-250621

transcription factor 4

IDBP-250623

transcription factor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18854153

[Homo sapiens] Transcription Factor that is an essential and specific regulator of Plasmacytoid dendritic cell development

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196628:
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011]
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box (\'E-box\') binding site (\'CANNTG\') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:69344146-69687967

Strand

Forward strand

Band

Transcripts

ENSMUST00000066717	ENSMUSP00000067318
ENSMUST00000078486	ENSMUSP00000077577
ENSMUST00000114985	ENSMUSP00000110636
ENSMUST00000114982	ENSMUSP00000110633
ENSMUST00000114980	ENSMUSP00000110631
ENSMUST00000114978	ENSMUSP00000110629
ENSMUST00000114977	ENSMUSP00000110628
ENSMUST00000128706
ENSMUST00000155695
ENSMUST00000125154
ENSMUST00000126946
ENSMUST00000136151
ENSMUST00000145918
ENSMUST00000146908
ENSMUST00000136019

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	42 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001011	sequence-specific DNA binding RNA polymerase recruiting transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001087	TFIIB-class binding transcription factor activity
GO:0001093	TFIIB-class transcription factor binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0065004	protein-DNA complex assembly

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000196628

View Gene Order

ENSBTAG00000016462

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_5

ID pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_8

Wnt pathway

REACTOME

REACT_21402

CDO in myogenesis pathway

REACT_111045

Developmental Biology pathway

REACT_21303

Myogenesis pathway

KEGG

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

Cross-References

SwissProt

Q60722

TrEMBL

E9Q8G4 Q91XK1 Q91YV0

UniProt Splice Variant

Entrez Gene

21413

UniGene

Mm.394316 Mm.4269 Mm.457828 Mm.470505 Mm.485755

RefSeq

NM_001083967 NM_013685 XM_006525746 XM_006525747 XM_006525748 XM_006525749 XM_006525750 XM_006525751 XM_006525752 XM_006525753 XM_006525754 XM_006525755 XM_006525756 XM_006525757 XM_006525758 XM_006525759 XM_006525764 XM_006525765

OMIM

CCDS

CCDS29329 CCDS50315

HPRD

IMGT

MGI ID

MGI:98506

MGI Symbol

Tcf4

EMBL

AC109258 AC157576 AC163095 AC167546 AC169193 AK014343 AK081012 AK151433 BC014293 BC043050 CH466528 S75870 U16321 U16322 X91753

GenPept

AAB32662 AAC52414 AAC52415 AAH14293 AAH43050 BAB29285 BAC38116 BAE30396 CAA62868 EDL09593

RNA Seq Atlas

21413